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sshmm 1.0.1

A sequence-structure hidden Markov model for the analysis of RNA-binding protein data.

RNA-binding proteins (RBPs) play a vital role in the post-transcriptional control of RNAs. They are known to recognize RNA molecules by their nucleotide sequence as well as their three-dimensional structure. ssHMM is an RNA motif finder that combines a hidden Markov model (HMM) with Gibbs sampling to learn the joint sequence and structure binding preferences of RBPs from high-throughput RNA-binding experiments, such as CLIP-Seq. The model can be visualized as an intuitive graph illustrating the interplay between RNA sequence and structure.

 
File Type Py Version Uploaded on Size
sshmm-1.0.1.tar.gz (md5) Source 2017-07-31 100KB